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Molecular Image Detail
Image
Caption Overview of the scheme for generating the Nrastm1.1Emfu, Nrastm2.1Emfu, Nrastm3Emfu, and Nrastm4Emfu alleles. (A) Schematic representation of Nras. Arrows indicate the identified Akv 1-99 proviral integrations (integration 3, 9 and 11). Boxes represent exons and the coding region is depicted in black. (B) Representation of the "targeting cassettes" introduced in the sense (S) and antisense (AS) knock-in models. Upon expression of Cre recombinase a LoxP sequence (triangle) and the neomycin selection marker (Neo) can be removed from the construct. Integration 3 results in the Nrastm3Emfu and Nrastm4Emfu alleles. Integration 9 results in the Nrastm1.1Emfu and Nrastm2.1Emfu alleles. LTR = long terminal repeat.
Copyright This image is from Ballarin-Gonzalez B, PLoS One 2013;8(2):e56029, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199340
Associated
Alleles
Symbol Name
Nrastm2.1Emfu neuroblastoma ras oncogene; targeted mutation 2.1, Ernst-Martin Fuchtbauer
Nrastm3Emfu neuroblastoma ras oncogene; targeted mutation 3, Ernst-Martin Fuchtbauer
Nrastm4Emfu neuroblastoma ras oncogene; targeted mutation 4, Ernst-Martin Fuchtbauer

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory