Molecular Image Detail

Image

Caption

Overview of the scheme for generating the Nras^tm1.1Emfu, Nras^tm2.1Emfu, Nras^tm3Emfu, and Nras^tm4Emfu alleles. (A) Schematic representation of Nras. Arrows indicate the identified Akv 1-99 proviral integrations (integration 3, 9 and 11). Boxes represent exons and the coding region is depicted in black. (B) Representation of the "targeting cassettes" introduced in the sense (S) and antisense (AS) knock-in models. Upon expression of Cre recombinase a LoxP sequence (triangle) and the neomycin selection marker (Neo) can be removed from the construct. Integration 3 results in the Nras^tm3Emfu and Nras^tm4Emfu alleles. Integration 9 results in the Nras^tm1.1Emfu and Nras^tm2.1Emfu alleles. LTR = long terminal repeat.

This image is from Ballarin-Gonzalez B, PLoS One 2013;8(2):e56029, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199340

Associated
Alleles

Symbol	Name
Nras^tm2.1Emfu	neuroblastoma ras oncogene; targeted mutation 2.1, Ernst-Martin Fuchtbauer
Nras^tm3Emfu	neuroblastoma ras oncogene; targeted mutation 3, Ernst-Martin Fuchtbauer
Nras^tm4Emfu	neuroblastoma ras oncogene; targeted mutation 4, Ernst-Martin Fuchtbauer

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