Phenotype Image Detail

Image

Caption

Urm1^em1(IMPC)J/Urm1^em1(IMPC)J (Urm1-/-) embryonic phenotype. Urm1-/- embryos are smaller than their littermates at E8.5 and display a range of phenotypes. While a minority of E8.5 Urm1-/- embryos appear normal as the embryo on the top, a minority are abnormal as the embryo in the middle, the majority of mutants are delayed (as the embryo on the bottom) when compared with littermates. At E9.5 almost all Urm1-/- embryos are delayed when compared with control littermates. Almost all E9.5 Urm1-/- embryos display incomplete turning and abnormal head shape, and most mutants appear to have abnormal branchial arches. Phenotypes present in half of E9.5 Urm1-/- embryos include abnormal cranial neural tube closure, abnormal cardiac development and slight neural tube kinking. By E10.5 Urm1-/- embryos that are not dying are all delayed and display abnormal head shape and slight neural tube kinking.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Urm1^em1(IMPC)J	ubiquitin related modifier 1; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Urm1^em1(IMPC)J/Urm1^em1(IMPC)J	C57BL/6NJ-Urm1^em1(IMPC)J/Mmjax