Phenotype Image Detail

Image

Caption

Placental phenotype in Stt3b^em1(IMPC)J/Stt3b^em1(IMPC)J (Stt3b-/-) embryos. At E9.5, Stt3b-/- placentas display multiple labyrinth zone (LZ) defects compared to controls. In KO placentas, chorioallantoic branching is impaired compared to controls. Although the Tfeb+ labyrinth trophoblast layer is comparable to controls, signal intensity appears elevated, suggesting a higher density of Tfeb+ cells. While this phenotype appears mild in the representative placenta shown, it is more pronounced when comparing all three KOs directly to the three controls. At E10.5, Stt3b-/- placentas exhibit multiple LZ defects compared to controls. In KO placentas, the Tfeb+ labyrinth trophoblast layer is slightly reduced in thickness but the Tfeb signal intensity appears elevated, suggesting an increased density of Tfeb+ cells. While this phenotype appears mild in the representative placenta shown, it is more pronounced when comparing all three KOs directly to the three controls. Chorioallantoic branching is also severely impaired.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Stt3b^em1(IMPC)J	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae); endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Stt3b^em1(IMPC)J/Stt3b^em1(IMPC)J	C57BL/6NJ-Stt3b^em1(IMPC)J/Mmjax