Phenotype Image Detail

Image

Caption

E8.5 Rprd2^em1(IMPC)J/Rprd2^em1(IMPC)J (Rprd2-/-) embryos appear relatively normal but are often delayed compared to controls. Most E9.5 Rprd2-/- embryos are delayed, some more severely than others, most are not turned or display incomplete turning, however because of the severe delay is not always counted. Approximately half of E9.5 Rprd2-/- display mild caudal neural tube kinks. Almost all display abnormal head shape and also display incomplete cranial neural tube closure, which may also be due to the delay. Many display abnormal heart morphology and a minority of those with intact yolk sacs after dissection have abnormal yolk sacs. A few Rprd2-/- embryos at both E8.5 and 9.5 have a circular tissue above their head folds (as is the case for the younger E8.5 mutant in the image) which appears to result from inappropriate resolution of the amnionic cavity.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Rprd2^em1(IMPC)J	regulation of nuclear pre-mRNA domain containing 2; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Rprd2^em1(IMPC)J/Rprd2^em1(IMPC)J	C57BL/6NJ-Rprd2^em1(IMPC)J/Mmjax