Phenotype Image Detail

Image

Caption

Placental phenotypes in Chp1^em1(IMPC)Tcp/Chp1^em1(IMPC)Tcp (Chp1-/-) mice. At E9.5, Chp1-/- placenta exhibit a diminished Tpbpa+ spongiotrophoblast layer, impaired chorioallantoic attachment, and multiple labyrinth zone defects compared to controls. In the KO placentas, the Tfeb+ region fails to expand, remaining a thin layer, and Gcm1+ chorioallantoic branching is severely impaired. Impaired chorioallantoic attachment is observed in most KO conceptuses examined (KO #2, n = 3/4). Although allantoic mesoderm is present adjacent to the chorion, the attachment appears weak and is easily disrupted during dissection. In the conceptus with normal attachment (KO #1, n = 1/4), less allantoic mesoderm is observed, and the resulting interface fails to expand as widely as in controls.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Chp1^em1(IMPC)Tcp	calcineurin-like EF hand protein 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Associated Genotypes

Allelic Composition	Genetic Background
Chp1^em1(IMPC)Tcp/Chp1^em1(IMPC)Tcp	C57BL/6NCrl-Chp1^em1(IMPC)Tcp/TcpMmucd