Phenotype Image Detail

Image

Caption

Placental phenotype in Bltp2^em1(IMPC)J/Bltp2^em1(IMPC)J (Bltp2 -/-) mice. At E9.5, Bltp2-/- placentas are properly developed and comparable to control littermates. At E10.5, Bltp2-/- placentas exhibit a diminished Tpbpa+ spongiotrophoblast (SpT) layer and moderate labyrinth zone (LZ) defects compared to controls. While the SpT layer abnormality is consistently observed in all Bltp2-/- placentas examined (n=4), the LZ defects are not fully penetrant, and their severity correlates with that of the embryonic phenotype. In one Bltp2-/- placenta, the LZ develops normally whereas in two of four Bltp2-/- placentas, the Tfeb+ labyrinth trophoblast layer is markedly reduced. Gcm1+ chorioallantoic branching is impaired in three of the 4 Bltp2-/- placentas.

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Kimberly D. Tremblay at kdtrembl@umass.edu. J:374598

Associated Alleles

Symbol	Name
Bltp2^em1(IMPC)J	bridge-like lipid transfer protein family member 2; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Bltp2^em1(IMPC)J/Bltp2^em1(IMPC)J	C57BL/6NJ-Bltp2^em1(IMPC)J/Mmjax