Phenotype Image Detail

Image

Caption

IL-33 is required for development of an IgE/mast cell independent OVA-induced allergic airway hypersensitivity response. Wild-type (IL-33+/+) and Il33^tm1Snak/Il33^tm1Snak (IL-33-/-) mice were sensitized twice with OVA emulsified in alumon days 0 and 14. The mice were challenged intranasally with OVA or saline alone on days 28, 29, and 30. Lung sections stained with hematoxylin-eosin (C) (100X representative data from three to five mice are shown) at 24 hours after the last OVA or PBS inhalation. Data show the mean SE: *P < 0.05 vs. corresponding values for saline-treated mice; P < 0.05 vs. OVA-treated mutant mice.

Copyright

This image is from Oboki K, Proc Natl Acad Sci U S A 2010 Oct 26;107(43):18581-6. Copyright 2010 National Academy of Sciences, U.S.A. J:165513

Associated Alleles

Symbol	Name
Il33^tm1Snak	interleukin 33; targeted mutation 1, Susumu Nakae

Associated Genotypes

Allelic Composition	Genetic Background
Il33^tm1Snak/Il33^tm1Snak	involves: C57BL/6 * CBA