Il33^tm1Snak
Targeted Allele Detail

Summary

• Symbol: Il33^tm1Snak
• Name: interleukin 33; targeted mutation 1, Susumu Nakae
• MGI ID: MGI:4838250
• Synonyms: Il33^gfp, IL-33 KO
• Gene: Il33 Location: Chr19:29902514-29938118 bp, + strand Genetic Position: Chr19, 24.56 cM, cytoband C2
• Alliance: Il33^tm1Snak page

Attenuated pulmonary inflammation in OVA-sensitized Il33^tm1Snak/Il33^tm1Snak mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165513
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a GFP and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:165513)

Generation of the Il33^tm1Snak allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il33 Mutation: 30 strains or lines available

References

• Original: J:165513 Oboki K, et al., IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18581-6
• All: 59 reference(s)