Phenotype Image Detail

Image

Caption

Correction of embryonic Cdkn1c^tm1Kat/Cdkn1c⁺ (p57^KO) mouse phenotypes in Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺ (p57^p27KI) mice. (A) Representative examples of the whole body, lens, and palate at E18.5, as well as of the intestine at P0. The growth retardation, cataracts in the lens (stained with hematoxylin-eosin), cleft palate (arrowhead), and short intestine of p57^KO mice were corrected in p57^p27KI mice. (Scale bars: macroscopic comparisons, 5 mm; lens sections, 100 um.) (B) Representative examples of the adrenal gland at P0. Vertical lines indicate comparison of the major axis between the glands from p57^KO and p57^p27KI mice. (C) Representative examples of skeletal staining of E18.5 embryos. Red and black arrowheads indicate the ossification of occipital bone and digits, respectively. (Scale bars: whole body, 5 mm; digits, humerus, and femur, 1 mm.)

Copyright

This image is from Susaki E, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5192-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147145

Associated Alleles

Symbol	Name
Cdkn1c^tm1.1(Cdkn1b*)Kei	cyclin dependent kinase inhibitor 1C; targeted mutation 1.1, Keiichi I Nakayama
Cdkn1c^tm1Kat	cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn1c^tm1.1(Cdkn1b*)Kei/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J
Cdkn1c^tm1Kat/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J