Phenotype Image Detail

Image

Caption

Representative images of Pikfyve^tm2.1Tssk/Pikfyve^tm2.1Tssk Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tg(Tyr-cre/ERT2)13Bos/0 (PlKfyve^Flox/Flox, mTmG+, Cre+) mice and Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tg(Tyr-cre/ERT2)13Bos/0 (PIKfyve^+/+, mTmG+, Cre+) control mice at P50. Note the early greying phenotype shown here is similar to what is observed in Pikfyve^tm2.1Tssk/Pikfyve^tm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0 mice at p50.

Copyright

This image is from Liggins MC, PLoS Genet 2018 Mar;14(3):e1007290, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:262141

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo	gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Liqun Luo
Pikfyve^tm2.1Tssk	phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 2.1, Takehiko Sasaki
Tg(Tyr-cre/ERT2)13Bos	transgene insertion 13, Marcus Bosenberg

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Pikfyve^tm2.1Tssk/Pikfyve^tm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0	involves: C57BL/6 * C57BL/6J