Phenotype Image Detail

Image

Caption

Whole mounts of a representative E13.5 litter derived from mating Apc^tm1Tno/Apc^tm1Tno Ctnnb1⁺/Ctnnb1⁺ with Apc^Min/Apc⁺ Ctnnb1^tm4.1Wbm/Ctnnb1⁺ mice. N = total number of embryos recovered for the indicated genotypes. Genotypes are as follows: Apc^+/fl (+/fl; Apc⁺/Apc^tm1Tno); Apc^min/fl (min/fl; Apc^Min/Apc^tm1Tno); Apc^min/fl; Ctnnb1^+/- (min/fl;ctnnb1+/-; Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺); Apc^+/fl;Ctnnb1^+/- (+/fl;ctnnb1+/-; Apc⁺/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺).

Copyright

This image is from Buchert M, PLoS Genet 2010 Jan;6(1):e1000816, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:156864

Associated Alleles

Symbol	Name
Apc^Min	APC, WNT signaling pathway regulator; multiple intestinal neoplasia
Apc^tm1Tno	APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda
Ctnnb1^tm4.1Wbm	catenin beta 1; targeted mutation 4.1, Walter Birchmeier

Associated Genotypes

Allelic Composition	Genetic Background
Apc^Min/Apc^tm1Tno	involves: 129 * 129S4/SvJae * C57BL/6
Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1^+	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6