Phenotype Image Detail

Image

Caption

Requirement of Elav1 (HuR) for postnatal hematopoiesis. (A) Atrophy of spleen, thymus, and LN (L) 4 days after deletion of Elavl1. (B) H&E stain of tissue sections from Elavl1^tm1Thla/Elavl1^tm1Thla (Elavl1^f/f) and Elavl1^tm1Thla/Elavl1^tm1Thla Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ (Elavl1^delta/delta) mice 4 days after tamoxifen treatment. Original magnification, 5 (spleen, thymus, and LN); 40 (BM). Scale bar: 50 um (spleen, thymus, and LN); 20 um (bone). B, BM. (C) Elavl1^f/f and Elavl1^delta/delta mice were treated with tamoxifen, and the total number of BM cells and thymocytes were counted at indicated times (*P < 0.05; n = 5).

Copyright

This image is from Ghosh M, J Clin Invest 2009 Dec;119(12):3530-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:155109

Associated Alleles

Symbol	Name
Elavl1^tm1Thla	ELAV like RNA binding protein 1; targeted mutation 1, Timothy Hla
Gt(ROSA)26Sor^tm1(cre/ERT2)Alj	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alexandra L Joyner

Associated Genotypes

Allelic Composition	Genetic Background
Elavl1^tm1Thla/Elavl1^tm1Thla Gt(ROSA)26Sor^tm1(cre/ERT2)Alj/Gt(ROSA)26Sor^+	involves: 129