Elavl1^tm1Thla
Targeted Allele Detail

Summary

• Symbol: Elavl1^tm1Thla
• Name: ELAV like RNA binding protein 1; targeted mutation 1, Timothy Hla
• MGI ID: MGI:4414853
• Synonyms: Elavl1^f, HuR^fl
• Gene: Elavl1 Location: Chr8:4335382-4375413 bp, - strand Genetic Position: Chr8, 2.0 cM
• Alliance: Elavl1^tm1Thla page

Cachexic phenotype of Elavl1^tm1Thla/Elavl1^tm1Thla Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ mice observed 4 days after tamoxifen administration

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and an frt and loxP site was inserted downstream of exon 5. (J:155109)

Generation of the Elavl1^tm1Thla allele

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elavl1 Mutation: 43 strains or lines available

References

• Original: J:155109 Ghosh M, et al., Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. 2009 Dec;119(12):3530-43
• All: 21 reference(s)