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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elavl1tm1Thla
targeted mutation 1, Timothy Hla
MGI:4414853
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Elavl1tm1Thla/Elavl1tm1Thla
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+ 		involves: 129 MGI:4414940


Genotype
MGI:4414940
cn1
Allelic
Composition		 Elavl1tm1Thla/Elavl1tm1Thla
Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1tm1Thla mutation (1 available); any Elavl1 mutation (43 available)
Gt(ROSA)26Sortm1(cre/ERT2)Alj mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cachexic phenotype of Elavl1tm1Thla/Elavl1tm1Thla Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+ mice observed 4 days after tamoxifen administration

mortality/aging
premature death ( J:155109 )
• 10 days after tamoxifen treatment

immune system
increased T cell apoptosis ( J:155109 )
• following tamoxifen treatment, double positive T cells in the thymus exhibit increased apoptosis and necrosis and decreased proliferation compared with T cells from Elavl1tm1Hela homozygotes
thymus hypoplasia ( J:155109 )
• following tamoxifen treatment
decreased leukocyte cell number ( J:155109 )
• 65% 4 days following tamoxifen treatment
decreased double-positive T cell number ( J:155109 )
• following tamoxifen treatment
abnormal myeloid leukocyte morphology ( J:155109 )
• following tamoxifen treatment, myeloid cell numbers are decreased compared to in Elavl1tm1Hela homozygotes
decreased granulocyte number ( J:155109 )
• 4 days following tamoxifen treatment
increased granulocyte number ( J:155109 )
• 2-fold following tamoxifen treatment
spleen hypoplasia ( J:155109 )
• following tamoxifen treatment
abnormal B cell physiology ( J:155109 )
• following tamoxifen treatment, early B cells exhibit increased apoptosis and necrosis and decreased proliferation compared with B cells from Elavl1tm1Hela homozygotes
decreased B cell apoptosis ( J:155109 )
• following tamoxifen treatment, early B cells exhibit increased apoptosis and necrosis and decreased proliferation compared with B cells from Elavl1tm1Hela homozygotes
lymph node hypoplasia ( J:155109 )
• following tamoxifen treatment

hematopoietic system
increased T cell apoptosis ( J:155109 )
• following tamoxifen treatment, double positive T cells in the thymus exhibit increased apoptosis and necrosis and decreased proliferation compared with T cells from Elavl1tm1Hela homozygotes
thymus hypoplasia ( J:155109 )
• following tamoxifen treatment
abnormal definitive hematopoiesis ( J:155109 )
• bone marrow from tamoxifen-treated mice exhibits decreased myeloerythroid colonies on methylcellulose compared with bone marrow from Elavl1tm1Hela homozygotes
decreased common myeloid progenitor cell number ( J:155109 )
• following tamoxifen treatment
decreased bone marrow cell number ( J:155109 )
• following tamoxifen treatment, total bone marrow cell numbers and bone marrow cellularity of immature cells are decreased compared to in Elavl1tm1Hela homozygotes
decreased erythroid progenitor cell number ( J:155109 )
• following tamoxifen treatment
decreased leukocyte cell number ( J:155109 )
• 65% 4 days following tamoxifen treatment
decreased double-positive T cell number ( J:155109 )
• following tamoxifen treatment
abnormal myeloid leukocyte morphology ( J:155109 )
• following tamoxifen treatment, myeloid cell numbers are decreased compared to in Elavl1tm1Hela homozygotes
decreased granulocyte number ( J:155109 )
• 4 days following tamoxifen treatment
increased granulocyte number ( J:155109 )
• 2-fold following tamoxifen treatment
spleen hypoplasia ( J:155109 )
• following tamoxifen treatment
abnormal B cell physiology ( J:155109 )
• following tamoxifen treatment, early B cells exhibit increased apoptosis and necrosis and decreased proliferation compared with B cells from Elavl1tm1Hela homozygotes
decreased B cell apoptosis ( J:155109 )
• following tamoxifen treatment, early B cells exhibit increased apoptosis and necrosis and decreased proliferation compared with B cells from Elavl1tm1Hela homozygotes

digestive/alimentary system
abnormal intestinal epithelium morphology ( J:155109 )
• 2 to 3 days following tamoxifen treatment, mice exhibit massive villus atrophy and disruption of the epithelial architecture unlike Elavl1tm1Hela homozygotes
abnormal intestinal mucosa morphology ( J:155109 )
• disrupted following tamoxifen treatment
abnormal intestinal goblet cell morphology ( J:155109 )
• following tamoxifen treatment, goblet cells are lost unlike in Elavl1tm1Hela homozygotes
abnormal crypts of Lieberkuhn morphology ( J:155109 )
• following tamoxifen treatment, proliferation of crypt progenitor cells is decreased while apoptosis is increased unlike in Elavl1tm1Hela homozygotes
abnormal colon morphology ( J:155109 )
• following tamoxifen treatment, apoptosis of cells in the lamina propria and epithelial cells of the colon is increased compared to in Elavl1tm1Hela homozygotes
small intestinal villus atrophy ( J:155109 )
• 2 to 3 days following tamoxifen treatment, mice exhibit massive villus atrophy unlike Elavl1tm1Hela homozygotes
distended stomach ( J:155109 )
• 2 to 4 days following tamoxifen treatment
intestinal obstruction ( J:155109 )
• 2 to 4 days following tamoxifen treatment the proximal intestine is devoid of food suggesting intestinal blockage

growth/size/body
cachexia ( J:155109 )
• following tamoxifen treatment

cellular
abnormal intestinal goblet cell morphology ( J:155109 )
• following tamoxifen treatment, goblet cells are lost unlike in Elavl1tm1Hela homozygotes
decreased B cell apoptosis ( J:155109 )
• following tamoxifen treatment, early B cells exhibit increased apoptosis and necrosis and decreased proliferation compared with B cells from Elavl1tm1Hela homozygotes
increased T cell apoptosis ( J:155109 )
• following tamoxifen treatment, double positive T cells in the thymus exhibit increased apoptosis and necrosis and decreased proliferation compared with T cells from Elavl1tm1Hela homozygotes
decreased cell proliferation ( J:155109 )
• mouse embryonic fibroblasts treated with 4-hydoxytamoxifen exhibit decreased proliferation compared with similarly treated cells from Elavl1tm1Hela homozygotes

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:155109 )
• following tamoxifen treatment, proliferation of crypt progenitor cells is decreased while apoptosis is increased unlike in Elavl1tm1Hela homozygotes
thymus hypoplasia ( J:155109 )
• following tamoxifen treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory