Phenotype Image Detail

Image

Caption

Ferritin expression is increased in Ireb2^tm1.1Eal/Ireb2^tm1.1Eal (Irp2^-/-) neurons. Double immuno-fluorescence labeling of brain sections from male mutant and wild-type (WT) mice using ferritin antibody with either calbindin (Purkinje specific) or NeuN (neuronal nuclei) antibodies. A) Calbindin immunofluorescence shows that Purkinje cell number and morphology (yellow arrows, processes), are normal in the mutant cerebellum. B) Ferritin and calbindin double immune-fluorescence of cerebellum shows similar ferritin expression in mutant and WT Purkinje neurons. C) Ferritin and NeuN double immunofluorescence of hippocampal CA1 pyramidal cell layer, and D) caudate putamen shows increased ferritin expression in neuronal cell bodies (yellow arrows) of mutant mice compared to WT mice. Increased ferritin staining is observed in the neuropil in the hippocampus and caudate putamen of mutant mice. Scale bars: 50 um.

Copyright

This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335

Associated Alleles

Symbol	Name
Ireb2^tm1.1Eal	iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold

Associated Genotypes

Allelic Composition	Genetic Background
Ireb2^tm1.1Eal/Ireb2^tm1.1Eal	B6J.129-Ireb2^tm1.1Eal