Ireb2^tm1.1Eal
Targeted Allele Detail

Summary

• Symbol: Ireb2^tm1.1Eal
• Name: iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
• MGI ID: MGI:5702744
• Synonyms: Irp2^-
• Gene: Ireb2 Location: Chr9:54771073-54819814 bp, + strand Genetic Position: Chr9, 29.81 cM
• Alliance: Ireb2^tm1.1Eal page

Iron accumulates in specific brain regions of Ireb2^tm1.1Eal/Ireb2^tm1.1Eal mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217335
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A construct containing a FLAG-tagged human ACO1 cDNA and a self-excising neo cassette was inserted into exon 3. mRNA expression of the FLAG-tagged human cDNA is detected but no protein expression is detected. (J:217335)

Generation of the Ireb2^tm1.1Eal allele

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ireb2 Mutation: 61 strains or lines available

References

• Original: J:217335 Zumbrennen-Bullough KB, et al., Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PLoS One. 2014;9(6):e98072
• All: 2 reference(s)