Phenotype Image Detail

Image

Caption

(A-F) H&E-stained lung tissue sections from newborn Lpcat1^{Gt(BC0405)Wtsi}/Lpcat1^{Gt(BC0405)Wtsi} (Lpcat1^GT/GT) mice that succumbed from respiratory distress syndrome (RDS), showing areas of atelectasis and hemorrhaging (C, arrow) compared with less-affected areas in the same lung (C, arrowhead) and lungs of an asymptomatic mutant (B) and wild-type littermates (A). (D-F) High-power magnifications of areas boxed in A-C. ABCA3 protein levels were assessed by immunostaining (G-I). Scale bars: 500 um (A-C), 100 um (D-F), 50 um (G-I).

Copyright

This image is from Bridges JP, J Clin Invest 2010 May 3;120(5):1736-48 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:161467

Associated Alleles

Symbol	Name
Lpcat1^Gt(BC0405)Wtsi	lysophosphatidylcholine acyltransferase 1; gene trap BC0405, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Lpcat1^Gt(BC0405)Wtsi/Lpcat1^Gt(BC0405)Wtsi	involves: 129P2/OlaHsd * Black Swiss