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Phenotype Image Detail
Image
Caption Spermatid differentiation arrest, germ cell sloughing and apoptosis lead to sterility in the Rbm5sda/Rbm5sda males. (A) Intact testes and (B) testis weight of wild-type (WT/WT) and mutant (sda/sda) adult mice (8-week-old). (C) Periodic acid-Schiff stained testis sections at stage VII-VIII and (D) haematoxylin and eosin stained epididymis sections of WT and mutant adult mice. PS: pachytene spermatocyte, rST: round spermatid, eST: elongating and elongated spermatids; Sp: spermatozoa. D, arrowheads indicate sloughed immature germ cells. (E) Caspase 3 (CASP3) and (F) Caspase 9 (CASP9) immunostaining of WT and mutant adult testes. Brown staining represents apoptotic cells. (G) Numbers of Caspase 3 and (H) Casapse 9 positive cells per seminiferous tubule of WT and mutant adult testes. *p<0.01 (unpaired t-test).
Copyright This image is from O'Bryan MK, PLoS Genet 2013;9(7):e1003628, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223049
Associated
Alleles
Symbol Name
Rbm5sda RNA binding motif protein 5; spermatid differentiation arrest
Associated
Genotypes
Allelic Composition Genetic Background
Rbm5sda/Rbm5sda involves: C57BL/6J * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory