Rbm5^sda
Chemically induced Allele Detail

Summary

• Symbol: Rbm5^sda
• Name: RNA binding motif protein 5; spermatid differentiation arrest
• MGI ID: MGI:5563424
• Synonyms: Joey-RSA
• Gene: Rbm5 Location: Chr9:107617694-107648228 bp, - strand Genetic Position: Chr9, 59.07 cM
• Alliance: Rbm5^sda page

Spermatid differentiation arrest, germ cell sloughing and apoptosis lead to sterility in the Rbm5^sda/Rbm5^sda males

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: APF ENU Mutagenesis

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU mutagenesis induced a G to C point mutation at position 940 on cDNA (ENSMUST00000035199) in exon 10 that results in the amino acid substitution of Arginine to Proline at position 263 (R263P) within the second RNA recognition motif (RRM2). Genetic complementation data suggest that the R263P mutation results in a loss-of-function allele. (J:104190, J:223049) Inheritance: Recessive

Generation of the Rbm5^sda allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rbm5 Mutation: 52 strains or lines available

References

• Original: J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014
• All: 2 reference(s)