Phenotype Image Detail

Image

Caption

Spontaneous liver damage was confirmed by histological analysis on liver sections with H&E staining that showed inflammation and steatohepatitis at 12 weeks of age progressing to hepatocellular carcinoma (HCC) development in Ikbkg^tm1.1Chtr/Ikbkg^tm1.1Chtr Tg(Alb1-cre)7Gsc/0 and Ikbkg^tm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0 (NEMO^deltahepa) mice after 52 weeks.

This image is from Beraza N, J Exp Med 2009 Aug 3;206(8):1727-37, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:151485

Associated
Alleles

Symbol	Name
Ikbkg^tm1.1Chtr	inhibitor of kappaB kinase gamma; targeted mutation 1.1, Christian Trautwein
Tg(Alb1-cre)7Gsc	transgene insertion 7, Gunther Schutz

Associated
Genotypes

Allelic Composition	Genetic Background
Ikbkg^tm1.1Chtr/Ikbkg^tm1.1Chtr Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N * SJL
Ikbkg^tm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N * SJL
Ikbkg^tm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0	involves: C57BL/6 * FVB/N

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