Phenotype Image Detail

Image

Caption

Ptbp1^tm1Msol/Ptbp1^tm1Msol embryos show defects in yolk sac and placenta development. This figure compares yolk sac and placental structures in mutant and control embryos. A) Hematoxylin and eosin-stained paraffin sections of an E5.5 wild-type (WT) embryo, chosen for its comparable size to the null mutants, and an E7.5 yolk sac (left) juxtaposed with mutant E7.5 embryos and mutant yolk sacs, respectively (right). Mutants lack the typical structure of a normal embryo at this stage. If discernable at all, they lack a typical yolk sac with a thin Reichert's membrane in close proximity to trophoblast giant cells and the decidua. B) Immunofluorescence for collagen 4 on a section of a control E7.5 embryo is shown next to a similar image from a homozygous embryo. The control embryo shows collagen 4 signal from several basement membranes including the Reichert's membrane of the yolk sac. The null mutant, on the other hand, shows an unusually extended area high in collagen 4, not resembling a membrane.

Copyright

This image is from Suckale J, PLoS One 2011;6(2):e16992, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223915

Associated Alleles

Symbol	Name
Ptbp1^tm1Msol	polypyrimidine tract binding protein 1; targeted mutation 1, Michele Solimena

Associated Genotypes

Allelic Composition	Genetic Background
Ptbp1^tm1Msol/Ptbp1^tm1Msol	B6J.129-Ptbp1^tm1Msol