Phenotype Image Detail

Image

Caption

Fiber cells are disorganized in the cortical region of the lens in aged lens-specific Atg5^tm1Myok/Atg5^tm1Myok mice. A and B, Hematoxylin and eosin staining of the lens of 4-month-(M)-old (A) and 21-month-old (B) Atg5^tm1Myok/Atg5⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 (panels a-d) and Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 (panels e-h) mice. Magnified images of the indicated cortical region (panels c and g) and organelle-free zone (OFZ, panels d and h) are shown. Scale bars, 1 mm (panels a and e), 100 um (panels b and f), and 10 um (panels c, d, g, and h). C, Electron micrographs of fiber cells in the cortical region of the lens of 21-month-old mice. Magnified images of the indicated regions are shown in the right panels (panels a and b). Scale bars, 1 um.

Copyright

This image is from Morishita H, J Biol Chem 2013 Apr 19;288(16):11436-47 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198392

Associated Alleles

Symbol	Name
Atg5^tm1Myok	autophagy related 5; targeted mutation 1, Minesuke Yokoyama
Tg(Cryaa-cre)10Mlr	transgene insertion 10, Mike Robinson

Associated Genotypes

Allelic Composition	Genetic Background
Atg5^tm1Myok/Atg5^tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0	involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N