Phenotype Image Detail

Image

Caption

Scapular muscle dissection in adult wild-type (WT) and Fat1^{Gt(KST249)Byg}/Fat1^{Gt(KST249)Byg} Tg(Myl1-lacZ)1Ibdml/0 (Fat1^LacZ/LacZ) mice reveals a pronounced reduction in volume and thickness of the rhomboid superficialis (Rh. Sup.) and rhomboid profundus (Rb. P.). This likely underlies the scapular winging phenotype. In the top pictures, the trapezius cervicalis (Trap) has been removed on the right side of each mouse to uncover the other scapular muscles (rhomboids: Rho; levator scapula: LS). Yellow dotted lines indicate the extent of the scapula, red and orange dotted lines that of the two rhomboid muscles. The intermediate magnification highlights the respective shapes of the rhomboid superficialis (orange dotted line) and rhomboid profundus (purple dotted line). (G) Phalloidin staining of flat-mounted rhomboid superficialis muscles of WT and mutant mice at presymptomatic (middle panel) or advanced disease (20% wight loss; right-hand panel) stages shows that early defects of myofiber orientation precede reduction of myofibre diameter. Scale bars: (F) 2 mm; (G) 300 mm.

Copyright

This image is from Caruso N, PLoS Genet 2013 Jun;9(6):e1003550, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199157

Associated Alleles

Symbol	Name
Fat1^Gt(KST249)Byg	FAT atypical cadherin 1; gene trap KST249, BayGenomics
Tg(Myl1-lacZ)1Ibdml	transgene insertion 1, Developmental Biology Institue of Marseilles-Luminy

Associated Genotypes

Allelic Composition	Genetic Background
Fat1^Gt(KST249)Byg/Fat1^Gt(KST249)Byg Tg(Myl1-lacZ)1Ibdml/0	involves: 129P2/OlaHsd