Phenotype Image Detail

Image

Caption

Abolishment of retinal ganglion cells (RGCs) in Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 (Sox4/11-null) retinas. A-D, A'-D', F-I, F'-I', plastic sections of retinas isolated from 30-day-old control, Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 (Sox4-null) and Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(Six3-cre)69Frty/0 (Sox11-null) mice were analyzed by H&E staining (A, A', F, and F'), immunostaining of cryo-sections with anti-BRN3A (red) (B, B', G, and G'), immunostaining of whole-mount retina with anti-BRN3B (green) (C, C', H, and H') and SM132 (green) (D, D', I, and I'). K-N,K'-N', retinas of 14-day-old control mice and Sox4/11-null mice were analyzed with H&E staining (K and K'), immunostaining of cryo-sections with anti-BRN3A (red) (L, and L') and BRN3B (green) (M and M'). Immunostained sections with anti-BRN3A (red) and anti-BRN3B (green) were merged with DAPI staining pictures. E-E', J-J', O-O', ventral views of brains show thinner optic nerves (arrowheads) in Sox4-null and Sox11-null mice, and no optic nerves in Sox4/11-null mice.

Copyright

This image is from Jiang Y, J Biol Chem 2013 Jun 21;288(25):18429-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199663

Associated Alleles

Symbol	Name
Sox11^tm1.1Gan	SRY (sex determining region Y)-box 11; targeted mutation 1.1, Lin Gan
Sox4^tm1Vlf	SRY (sex determining region Y)-box 4; targeted mutation 1, Veronique Lefebvre
Tg(Six3-cre)69Frty	transgene insertion 69, Yasuhide Furuta

Associated Genotypes

Allelic Composition	Genetic Background
Sox11^tm1.1Gan/Sox11^tm1.1Gan Tg(Six3-cre)69Frty/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2