Phenotype Image Detail

Image

Caption

Phenotypic features of urethane-induced tumors in wild-type (Mmp1a^+/+) and Mmp1a^tm1Otin/Mmp1a^tm1Otin (Mmp1a^-/-) mice. A, graphic representation of size tumor incidence in males. Knock-out mice show a lower incidence of large tumors (> 10³ cells). B, inflammatory infiltrate incidence in both sexes. We represent the number of mice which present inflammatory infiltrate foci in their lungs, showing an increased presence of inflammatory foci in lungs from knock-out mice. Inflammatory infiltrates are indicated with arrows, and tumors are shown with arrowheads.

Copyright

This image is from Fanjul-Fernandez M, J Biol Chem 2013 May 17;288(20):14647-56 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198586

Associated Alleles

Symbol	Name
Mmp1a^tm1Otin	matrix metallopeptidase 1a (interstitial collagenase); targeted mutation 1, Carlos Lopez-Otin

Associated Genotypes

Allelic Composition	Genetic Background
Mmp1a^tm1Otin/Mmp1a^tm1Otin	involves: 129P2/OlaHsd * C57BL/6J