Mmp1a^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Mmp1a^tm1Otin
• Name: matrix metallopeptidase 1a (interstitial collagenase); targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:5514177
• Gene: Mmp1a Location: Chr9:7464141-7476857 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
• Alliance: Mmp1a^tm1Otin page

Phenotypic features of urethane-induced tumors in Mmp1a^tm1Otin/Mmp1a^tm1Otin mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198586
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced part of exon 4 through part of exon 6. Northern blot analysis confirmed the absence of transcript expression in the placenta. (J:198586)

Generation of the Mmp1a^tm1Otin allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp1a Mutation: 45 strains or lines available

References

• Original: J:198586 Fanjul-Fernandez M, et al., Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2013 May 17;288(20):14647-56
• All: 4 reference(s)