Phenotype Image Detail

Image

Caption

(K and L) Coronal sections of P1 mice with unilateral injection of Dil in the cerebellum. The arrow marks the midline. In control (K), Dil-labeled inferior olivary (IO) neurons are exclusively found on the contralateral side, whereas in Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache (Ptf1a::cre;Robo3^lox/lox) mice (L), most IO neurons are traced on the ipsilateral side, and their axons do not cross the midline. Scale bars represent 500 um except in (G and J), where they indicate 25 um, and in (K and L), where they indicate 150 um.

Copyright

This image is from Renier N, PLoS Biol 2010;8(3):e1000325, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158918

Associated Alleles

Symbol	Name
Ptf1a^tm1.1(cre)Cvw	pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright
Robo3^tm1.1Ache	roundabout guidance receptor 3; targeted mutation 1.1, Alain Chedotal

Associated Genotypes

Allelic Composition	Genetic Background
Ptf1a^tm1.1(cre)Cvw/Ptf1a^+ Robo3^tm1.1Ache/Robo3^tm1.1Ache	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ