Phenotype Image Detail

Image

Caption

Impaired pancreatic epithelial growth and branching morphogenesis in Sel1l^{Gt(CA0017)Wtsi}/Sel1l^{Gt(CA0017)Wtsi} (-/-) embryos. (A-D) Immunohistological analysis of the developing pancreas of wild-type (WT) and mutant embryos at E11.5 and E13.5; the genotypes of the pancreatic sections are indicated as +/+ and -/-, respectively. The following antibodies were used: Pdx1 (A-D, green) and insulin (C-D, red). (A-B) The dorsal and ventral pancreatic buds in mutant embryosare fused together. (C-D) The dorsal pancreatic bud of mutant embryos exhibits a markedly reduced epithelial size and an impaired branching morphology.

Copyright

This image is from Li S, BMC Dev Biol 2010;10():19, an open-access article, licensee BioMed Central Ltd. J:158780

Associated Alleles

Symbol	Name
Sel1l^Gt(CA0017)Wtsi	sel-1 suppressor of lin-12-like (C. elegans); gene trap CA0017, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Sel1l^Gt(CA0017)Wtsi/Sel1l^Gt(CA0017)Wtsi	involves: 129P2/OlaHsd