Phenotype Image Detail

Image

Caption

Rho^tm2.1Kpal/Rho^tm2.1Kpal (KK) mice undergo progressive retinal degeneration. (A) Representative 3D optical coherence tomography images of 2-month-old wild-type (WT) and Rho^tm2.1Kpal/Rho^tm2.1Kpal retinas. Scale bar: 20 um. The outer nuclear layer (ONL) was substantially thinner in retinas of homozygous mutant mice. (C) Plastic sections of retinas stained with toluidine blue from WT, heterozygous (EK) and homozygous (KK) mice at 1 and 4 months of age. Heterozygous mutant retina displayed an intermediate progression of retinal degeneration indicated by modest degeneration by 4 months of age that progressed to nearly complete loss of photoreceptors by 10 months of age.

Copyright

This image is from Zhang N, J Clin Invest 2013 Jan 2;123(1):121-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194158

Associated Alleles

Symbol	Name
Rho^tm2.1Kpal	rhodopsin; targeted mutation 2.1, Krzysztof Palczewski

Associated Genotypes

Allelic Composition	Genetic Background
Rho^tm2.1Kpal/Rho^+	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Rho^tm2.1Kpal/Rho^tm2.1Kpal	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac