Rhotm2.1Kpal
Targeted Allele Detail
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Symbol: |
Rhotm2.1Kpal |
Name: |
rhodopsin; targeted mutation 2.1, Krzysztof Palczewski |
MGI ID: |
MGI:5474849 |
Synonyms: |
RhoE150K |
Gene: |
Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
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Alliance: |
Rhotm2.1Kpal page
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Progressive retinal degeneration in heterozygous and homozygous Rhotm2.1Kpal mice
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:194158
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Parent Cell Line: |
iTL BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 2 was replaced with a floxed neo cassette and a modified exon 2 in which a G to A transition results in the amino acid substitution of lysine for glutamic acid (E150K). Cre-mediated recombination removed the neo cassette.
(J:194158)
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Targeting strategy for the generation of Rhotm2.1Kpal allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rho Mutation: |
48 strains or lines available
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Original: |
J:194158 Zhang N, et al., Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan 2;123(1):121-37 |
All: |
2 reference(s) |
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