Phenotype Image Detail

Image

Caption

Fgfr2^tm3Ewj/Fgfr2⁺ (+/Y394C) mice show abnormal histology, proliferation, and differentiation in the epidermis. (A-D) H&E staining shows the abnormal development of the mutant skin with cutis gyrata (corrugation), epidermal hyperplasia, and thickening at E16.5 and P0. The measurements of the thickness were performed at the top (t) and the bottom (b) of the troughs of the papillomatosis in the mutants. (E and F) Immunohistochemical staining of Ki67 shows increased numbers of positive cells in the basal layer of mutant epidermis at E16.5. (G-L) Immunohistochemical staining of differentiation markers show abnormal differentiation of (G and H) expression of K14 for basal layer, (I and J) expression of K10 for spinous layer, and (K and L) expression of loricrin for cornified and granular layers. (M and N) TUNEL mutant epidermis staining shows slight decrease of apoptosis in mutants. A, C, E, G, I, K, and M are from littermate controls. B, D, F, H, J, L, and N show the corresponding organs and tissues in mutant mice. Scale bars: 200 um (A and B); 50 um (C-N).

Copyright

This image is from Wang Y, J Clin Invest 2012 Jun 1;122(6):2153-64 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190491

Associated Alleles

Symbol	Name
Fgfr2^tm3Ewj	fibroblast growth factor receptor 2; targeted mutation 3, Ethylin Wang Jabs

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm3Ewj/Fgfr2^+	B6.129-Fgfr2^tm3Ewj