Gene Expression Image Detail

Reference

Figure

ID

J:78768 De Bellard M, et al., Dev Biol. 2002 Sep 1;249(1):121

2

MGI:5504006

Image

Caption

Whole-mount in situ hybridization at E9.5 and E10.5 in wild type (wt) and Dll1 mutant embryos. (a,e) Migrating neural crest cells at E9.5 (arrowheads). Arrow in (a) indicates discrete condensations of stained cells in wild type compared with relatively uniform population in a Dll1 embryo (arrow in e). (b, f) Higher magnification of the boxed area in (a) and (e). At the most rostral trunk region the dorsal root ganglion is beginning to condense (asterisks) and the position of the future sympathetic ganglia is indicated by an arrowhead. (c, g) Histological section through this region shows the neural crest migrating exclusively in the rostral half of the somite in a wild type embryo (R for rostral and C for caudal in c and g), while in the Dll1 mutant, the neural crest cells are entering both the rostral and caudal half of the somites (c, g). (d, f) E10.5, condensing DRG and sympathetic ganglia (DRG and SG, respectively) in wild type embryos (d); while Dll1 mutants are missing, the SG and the DRG are mostly fused (f). V and VII/VIII correspond to trigeminal and facial/auditory cranial ganglia, respectively.

Copyright

Reprinted with permission from Elsevier from 10.1006/dbio.2002.0756 Dev Biol 249: 121, De Bellard M; Ching W; Gossler A; Bronner-Fraser M, Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice. Copyright 2002

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
a	MGI:5504020 (Sox10)
b	MGI:5504020 (Sox10)
c	MGI:5504020 (Sox10)
d	MGI:5504020 (Sox10)
e	MGI:5504020 (Sox10)
f	MGI:5504020 (Sox10)
g	MGI:5504020 (Sox10)
h	MGI:5504020 (Sox10)