Phenotype Image Detail

Image

Caption

Increased osteolytic lesion formation and enhanced osteoclast activity in Ifngr1^tm1Agt/Ifngr1^tm1Agt Tg(GZMB-Tax)#Lera/0 mice (Tax+IFN-gamma-/-). a, representative x-rays of feet and tail vertebrae (<, osteolytic bone lesion; #, peripheral soft tumor). b, hematoxylin and eosin (H&E) and tartrate-resistant acid phosphatase (TRAP) stains on longitudinal sections of tail vertebrae. Increased numbers of TRAP-expressing osteoclasts are present in the tail vertebrae of mutants.

Copyright

This image is from Xu Z, J Biol Chem 2009 Feb 13;284(7):4658-66 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147601

Associated Alleles

Symbol	Name
Ifngr1^tm1Agt	interferon gamma receptor 1; targeted mutation 1, Michel Aguet
Tg(GZMB-Tax)#Lera	transgene insertion, Lee Ratner

Associated Genotypes

Allelic Composition	Genetic Background
Ifngr1^tm1Agt/Ifngr1^tm1Agt Tg(GZMB-Tax)#Lera/0	involves: 129S7/SvEvBrd * C57BL/6