Phenotype Image Detail

Image

Caption

Posterior view of a wild-type mouse illustrates the normal location of the aorta and efferent vessels (A). Posterior view of Ts(17¹⁶)65Dn/0 mouse shows an aberrant right subclavian artery (RSA) arising from the distal part of the aortic arch and describing a retrooesophagian loop (B). Haematoxylin-eosin staining of histological crosssections illustrates full septation of the ventricles with individualized valves in wild-type (C) while mutant heart cross-section shows an upper communication of the ventricles (D; arrow). This cardiovascular anomaly was observed in 1 in 18 mutant dead newborns. LSA, left subclavian artery; RSA, right subclavian artery; DA, descending aorta; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; Sept, septum; OT, outflow tract. Scale bars represent 1 mm in A, B and 400 um in C.

Copyright

This image is from Raveau M, PLoS Genet 2012 May;8(5):e1002724, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185269

Associated Alleles

Symbol	Name
Ts(17^16)65Dn	trisomy, Chr 16 translocation to Chr 17, Davisson 65

Associated Genotypes

Allelic Composition	Genetic Background
Ts(17^16)65Dn/0	involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J