Phenotype Image Detail

Image

Caption

Doxycycline-induced withdrawal of Mir155 leads to rapid tumor regression in Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0 mice. (A) Regression of enlarged lymph nodes in mutant mice exposed to doxycycline (n=10). (B) H&E spleens from mutant mice without doxycycline or on doxycycline for 48 hours or 2 weeks. In recovered mice, spleen architecture is restored similar to wild-type mice (n=10).

Copyright

This image is from Babar IA, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):E1695-704. Copyright 2012 National Academy of Sciences, U.S.A. J:185598

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(tTA,tetO-Mir155)Fjsl	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank J Slack
Tg(Nes-cre)1Wmz	transgene insertion 1, Weimin Zhong

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor^+ Tg(Nes-cre)1Wmz/0	involves: 129 * C57BL/6 * FVB/N * SJL/J