Phenotype Image Detail

Image

Caption

Homozygous mutant Cripto^tm1.1Gmin/Cripto^tm1.1Gmin (F78A) embryos initiate gastrulation but subsequently arrest development. Morphology of wild-type (WT) embryos (A-D) and mutant litter mates (A'-D') dissected at 7.5 (A and A'), 8.5 (B and B'), 9.5 (C and C'), and 10.5 (D and D') dpc. Both anterior and posterior structures that are absent in Tdgf1 (cripto)-null mutants (Ding et al., 1998 ; Liguori et al., 2003 ) can be clearly recognized at up to 8.5 dpc but subsequently deteriorate (C' and D'). Bars, 40 um.

Copyright

This image is from D'Andrea D, J Cell Biol 2008 Feb 11;180(3):597-605, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:186907

Associated Alleles

Symbol	Name
Cripto^tm1.1Gmin	cripto, EGF-CFC family member; targeted mutation 1.1, Gabriella Minchiotti

Associated Genotypes

Allelic Composition	Genetic Background
Cripto^tm1.1Gmin/Cripto^tm1.1Gmin	involves: 129S1/Sv * 129X1/SvJ * C57BL/6