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Criptotm1.1Gmin
Targeted Allele Detail
Summary
Symbol: Criptotm1.1Gmin
Name: cripto, EGF-CFC family member; targeted mutation 1.1, Gabriella Minchiotti
MGI ID: MGI:5433707
Synonyms: criptoF78A
Gene: Cripto  Location: Chr9:110768676-110775226 bp, - strand  Genetic Position: Chr9, 60.79 cM
Alliance: Criptotm1.1Gmin page
Arrested development in Criptotm1.1Gmin/Criptotm1.1Gmin embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186907
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA floxed pgk-neo cassette was inserted upstream of exon 3 and an F78A mutation was introduced via homologous recombination. Cre mediated recombination removed the neo cassette. Protein expression is confined to proximal epiblast in homozygous embryos. (J:186907)
Generation of the Criptotm1.1Gmin allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cripto Mutation:  55 strains or lines available
References
Original:  J:186907 D'Andrea D, et al., Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol. 2008 Feb 11;180(3):597-605
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory