Phenotype Image Detail

Image

Caption

Role of Fcgr4 in rheumatoid arthritis. (A) The development of clinical signs of arthritis in wild-type and Fcgr4^tm1.1Rav/Fcgr4^tm1.1Rav (FcgammaRIV-/-) mice upon injection of KBxN serum. (B) Measurement of the area of immigrated innate immune effector cells into the joints of wild-type and mutant animals (n=4). An asterisk in A and B indicates a significant difference with a p-value less than 0.05. (C) Histological analysis of inflamed joints of wild-type and mutant animals.

Copyright

This image is from Nimmerjahn F, Proc Natl Acad Sci U S A 2010 Nov 9;107(45):19396-401. Copyright 2010 National Academy of Sciences, U.S.A. J:167375

Associated Alleles

Symbol	Name
Fcgr4^tm1.1Rav	Fc receptor, IgG, low affinity IV; targeted mutation 1.1, Jeffrey V Ravetch

Associated Genotypes

Allelic Composition	Genetic Background
Fcgr4^tm1.1Rav/Fcgr4^tm1.1Rav	involves: C57BL/6