Fcgr4^tm1.1Rav
Targeted Allele Detail

Summary

• Symbol: Fcgr4^tm1.1Rav
• Name: Fc receptor, IgG, low affinity IV; targeted mutation 1.1, Jeffrey V Ravetch
• MGI ID: MGI:5428684
• Gene: Fcgr4 Location: Chr1:170846495-170857330 bp, + strand Genetic Position: Chr1, 78.53 cM
• Alliance: Fcgr4^tm1.1Rav page

Decreased susceptibility to induced arthritis in Fcgr4^tm1.1Rav/Fcgr4^tm1.1Rav mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167375
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1 and loxP sites were inserted downstream of exon 3. Cre-mediated recombination removed exons 1 through 3. Immunohistochemistry confirmed the absence of protein expression in splenic macrophage. (J:167375)

Generation of the Fcgr4^tm1Rav and Fcgr4^tm1.1Rav alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr4 Mutation: 22 strains or lines available

References

• Original: J:167375 Nimmerjahn F, et al., FcgammaRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19396-401
• All: 15 reference(s)