Phenotype Image Detail

Image

Caption

1(B) Morphology of E3.5 embryos derived from heterozygous Gnl3^{Gt(S4-4B1)Sor} intercrosses. Embryos were sorted into morphologically normal and abnormal sets. The first set was a mixture of wild-type (+/+) and heterozygous genotypes, the second set was exclusively Gnl3^{Gt(S4-4B1)Sor}/Gnl3^{Gt(S4-4B1)Sor}. Although littermate wild-type or heterozygous embryos formed blastocysts with a discernable blastocoel cavity (arrows), inner cell mass (stars), and trophectoderm (the outer cell layer surrounding the embryos) at E3.5, homozygous embryos resembled morulae and exhibited various degrees of morphological degeneration.

Copyright

This image is from Qu J, J Cell Biol 2012 Jun 11;197(6):731-45, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:185271

Associated Alleles

Symbol	Name
Gnl3^Gt(S4-4B1)Sor	guanine nucleotide binding protein nucleolar 3; gene trap S4-4B1, Philippe Soriano

Associated Genotypes

Allelic Composition	Genetic Background
Gnl3^Gt(S4-4B1)Sor/Gnl3^Gt(S4-4B1)Sor	involves: 129S4/SvJaeSor * C57BL/6