Phenotype Image Detail

Image

Caption

Reduction in post-meiotic germ cells is due to premature sloughing from the seminiferous epithelium. Sections of epididymides from homozygous Katnal1^1H/Katnal1^1H mice and wild-type (+/+) littermates were examined. In wild-type animals the epididymal lumen was filled with spermatozoa throughout the length of the epididymis (a, - boxed area enlarged in c). However, in homozygous mutant littermates, recognizable spermatozoa were almost absent, instead the caput and corpa epididymides contained immature, non-condensed, germ cells (b), which collected as a plug of proteinaceous cellular debris (*) in the cauda epididymis (b, boxed area enlarged in d). Bars = 20 um.

Copyright

This image is from Smith LB, PLoS Genet 2012 May;8(5):e1002697, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185195

Associated Alleles

Symbol	Name
Katnal1^1H	katanin p60 subunit A-like 1; ENU mutation 1, Harwell

Associated Genotypes

Allelic Composition	Genetic Background
Katnal1^1H/Katnal1^1H	involves: C3H/HeH * C57BL/6J