Katnal11H
Chemically induced Allele Detail
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Symbol: |
Katnal11H |
Name: |
katanin p60 subunit A-like 1; ENU mutation 1, Harwell |
MGI ID: |
MGI:5309172 |
Gene: |
Katnal1 Location: Chr5:148808394-148865978 bp, - strand Genetic Position: Chr5, 89.04 cM
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Alliance: |
Katnal11H page
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Katnal11H/Katnal11H mice show disruption of the seminiferous epithelium associated with a reduction in numbers of post-meiotic germ cells
Show the 4 phenotype image(s) involving this allele.
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: A single point mutation (T to G) is located in exon 7. This point mtation results in a leucine to
valine substitution at residue 286, within a conserved ATPase domain and creates a novel HpyAV restriction-enzyme recognition site. In vitro analysis indicates that this is a loss of function allele. In Sertoli cells from homozygous mice protein is restricted to the basal compartment rather than being throughout the basal and adluminal compartments.
(J:185195)
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Inheritance: |
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Recessive |
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Schematic of the Katnal11H allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Katnal1 Mutation: |
23 strains or lines available
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Original: |
J:185195 Smith LB, et al., KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility. PLoS Genet. 2012 May;8(5):e1002697 |
All: |
2 reference(s) |
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