Phenotype Image Detail

Image

Caption

Maternal retinaldehyde (Ral) rescues organ defects in Rdh10^tm1.1Ics/Rdh10^tm1.1Ics mutants that cannot be rescued by retinoic acid (RA) treatment. (A-H) Profile and frontal views of the heads from E13.5 control (WT, A and B) and Rdh10^tm1.1Ics/Rdh10^tm1.1Ics (Rdh10^-/-) mutants obtained after maternal supplementation with RA (C-F) or Ral (G and H) from E7.5 to E9.5. The variable rescue of facial defects in RA-rescued mutants is shown (C and E, asterisks). Ral-treated fetuses selectively display reduced palpebral fissure (G, red arrowhead). (I-T) Histological sections of heart ventricles (I-K; details in L-N), large arterial vessels (O-Q), and lungs (R-T) of WT, RA-treated, and Ral-treated Rdh10^tm1.1Ics/Rdh10^tm1.1Ics fetuses. Ao, aorta; CL, myocardial compact layer; Ep, epicardium; Lu (L/R), left/right lung; LV, left ventricle; Oe, esophagus; PT, pulmonary trunk; RV, right ventricle; TA, truncus arteriosus; TL, myocardial trabecular layer.

Copyright

This image is from Rhinn M, Proc Natl Acad Sci U S A 2011 Oct 4;108(40):16687-92. Copyright 2011 National Academy of Sciences, U.S.A. J:177362

Associated Alleles

Symbol	Name
Rdh10^tm1.1Ics	retinol dehydrogenase 10 (all-trans); targeted mutation 1.1, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Rdh10^tm1.1Ics/Rdh10^tm1.1Ics	involves: C57BL/6 * SJL