Phenotype Image Detail

Image

Caption

Rab25 deficiency promotes colon adenoma formation in Apc^Min/Apc⁺ mice. Gross appearance of colons from Apc^Min/Apc⁺ (APC^Min/+;Rab25^+/+, +/+) and Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25^tm1Jrgo (APC^Min/+;Rab25^-/-, -/-) mice. Rab25-deficient mice showed an increase in tumor number as well as an increase in tumor size throughout the colon. (B) The size distribution of polyps in the colons of Apc^Min/Apc⁺ (+/+) (n = 7), Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25⁺ (+/-) (n = 16), and Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25^tm1Jrgo (-/-) mice (n = 12). Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25^tm1Jrgo (-/-) mice showed a significant increase in colon tumor numbers (**P < 0.01). Data represent mean +/- SEM. (C) Representative Swiss rolls of colon from Apc^Min/Apc⁺ (+/+) and Apc^Min/Apc⁺ Rab25^tm1Jrgo/Rab25^tm1Jrgo (-/-) mice showing the prominent increase in tumor size in the Rab25-deficient mice. Scale bars: 1 mm.

Copyright

This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733

Associated Alleles

Symbol	Name
Apc^Min	APC, WNT signaling pathway regulator; multiple intestinal neoplasia
Rab25^tm1Jrgo	RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring

Associated Genotypes

Allelic Composition	Genetic Background
Apc^Min/Apc^+	C57BL/6J-Apc^Min
Apc^Min/Apc^+ Rab25^tm1Jrgo/Rab25^tm1Jrgo	B6.Cg-Rab25^tm1Jrgo Apc^Min