Phenotype Image Detail

Image

Caption

Limb and axial skeleton phenotypes of the Zbtb16^7t/Zbtb16^7t mice. Panels on the left are wild-type (WT), and panels on the right are Zbtb16^7t/Zbtb16^7t (7t/7t). (A) Digits I-V are anterior to posterior, respectively. (B) Representative example of mutant hindlimb in which digit III has been duplicated (asterisk). (C) Wild-type has one calcaneus. (D) The tatus of the mutant is homeotically transformed into a calcaneus. The blue triangle indicates a metatarsal fusion of digits I and II. In contrast to the wild-type hindlimbs (E), the mutants (F) display a thinner tibia that appears to be homeotically transformed into a thicker fibula-like structure. The green arrow indicates a failure of the two bones to fuse. (G,H) A dorsal view shows that the total number of thoracic vertebrae are the same in both genotypes. However, whereas the wild-type has seven ribs attached to the sternum (I), mutants have up to 10 (J). "Clav" = clavicle.

Copyright

This image is from Ching YH, BMC Dev Biol 2010;10(1):33, an open-access article, licensee BioMed Central Ltd. J:160477

Associated Alleles

Symbol	Name
Zbtb16^7t	zinc finger and BTB domain containing 16; seven toes

Associated Genotypes

Allelic Composition	Genetic Background
Zbtb16^7t/Zbtb16^7t	involves: C3HeB/FeJ * C57BL/6J