Phenotype Image Detail

Image

Caption

Developmental defects in Sall4^tm1Brd/Sall4⁺ mice. (a) Exencephaly in E16.5 Sall4^tm1Brd/Sall4⁺ (m1/+) embryo. (b,c) Normal kidney (b) and hypoplastic kidney (c) of E16.5 mutant embryo. The hypoplastic kidney is smaller, without well defined zonation, scale bar, 1 mm. C, renal cortex; M, renal medulla. (d) Normal kidney from E16.5 mutant embryo exhibiting well formed glomeruli and tubules, scale bar, 500 um. (e) Hypoplastic kidney contains primitive nephrogenic vesicles and mesenchyme, scale bar, 500 um. G, glomerulus; CT, proximal and distal convoluted tubules; NV, nephrogenic vesicle; M, mesenchyme. (f) Lower anogenital tract abnormalities in adult mutant mice. The lower rectum, vagina and urethra all open into a persistent cloaca. UT, uterus; B, bladder; V, vagina, U, urethra; C, persistent cloaca; R, rectum; S, spinal column, scale bar, 1mm. (g-l) Hirschprung's disease in mutant mouse with bowel obstruction. (g,h) Enteric ganglion cells (arrow) in the intramural and submucosal plexuses of the large bowel in wild-type mouse, (g) H&E stained section, (h) acetyl cholinesterase staining, scale bar, 100 um. (i-l) Mutant mice with bowel obstruction. (i,j) Proximal dilated bowel with sparse enteric neurons (arrows), scale bar, 50 um. (k,l) Distal segment of bowel, enteric ganglion cells absent; scale bar, 50 um.

Copyright

This image is from Warren M, Genesis 2007 Jan;45(1):51-8, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:117866

Associated Alleles

Symbol	Name
Sall4^tm1Brd	spalt like transcription factor 4; targeted mutation 1, Allan Bradley

Associated Genotypes

Allelic Composition	Genetic Background
Sall4^tm1Brd/Sall4^+	involves: 129S7/SvEvBrd * C57BL/6J