Phenotype Image Detail

Image

Caption

Temporal analysis of inner ear pathologic changes in S1pr2^tm1Rlp/S1pr2^tm1Rlp mice. A and B show the gross structure of the vestibular maculae in S1pr2^tm1Rlp/S1pr2^tm1Rlp (Null) and wild-type (WT) mice at postnatal day 7 (A, utricular macula and two ampules; B, saccular macula). The bright white areas are the mass of otoconia. Note (arrows) the paucity of utricular otoconia in the mutant mouse and the large size of those that are present (A). amp, ampule; utr, utricule. Scale bar in A is 200 um and also applies to B. C-E illustrate the morphology of the middle turn of the cochlea at postnatal days 14, 21 and 120 in wild-type mice. F-H illustrate the middle turn of the cochlea at respective postnatal ages in mutant mice. Small arrows indicate defects in the stria vascularis. Arrowheads and the large arrows indicate damage to the sensory hair cells in the organ of Corti and spiral ganglion neurons (H), respectievly. sv, stria vascularis; oc, organ of Corti; sg, spiral ganglion neurons. Scale bar in C is 100 um and applies to D-H.

Copyright

This image is from Kono M, J Biol Chem 2007 Apr;282(14):10690-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:121165

Associated Alleles

Symbol	Name
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6