Phenotype Image Detail

Image

Caption

Comparison of placenta morphology in wild-type and Hs6st1^tm1Kkm/Hs6st1^tm1Kkm mice. Wild-type (+/+, A and C) and Hs6st1^tm1Kkm/Hs6st1^tm1Kkm (-/-, B and D) mice. The E15.5 placentas were stained with hematoxylin and eosin. The lower panels show a high magnification of the rectangle in the upper panels. The orange arrowheads indicate nucleated fetal red blood cells, and the green arrows indicate maternal red blood cells. In the labyrinthine zone of the mutant embryo placentas, there were reduced numbers of fetal red blood cells. The yellow arrow indicates the labyrinthine zone. De, maternal deciduas; Ch, chorionic plate; La, labyrinthine zone; Sp, spongiotrophoblast layer.

Copyright

This image is from Habuchi H, J Biol Chem 2007 May 25;282(21):15578-88 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:122656

Associated Alleles

Symbol	Name
Hs6st1^tm1Kkm	heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Koji Kimata

Associated Genotypes

Allelic Composition	Genetic Background
Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * C57BL/6