Hs6st1^tm1Kkm
Targeted Allele Detail

Summary

• Symbol: Hs6st1^tm1Kkm
• Name: heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Koji Kimata
• MGI ID: MGI:3715259
• Gene: Hs6st1 Location: Chr1:36107481-36145527 bp, + strand Genetic Position: Chr1, 15.15 cM, cytoband B
• Alliance: Hs6st1^tm1Kkm page

Hs6st1^tm1Kkm/Hs6st1^tm1Kkm mice exhibit growth retardation and abnormal eye, phalanges, and tarsus morphology

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122656
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.7kb fragment encoding the critical 3'-phosphoadenosine 5'-phosphosulfate binding site was replaced with a neo cassette. The absence of transcript was confirmed by northen blot. (J:122656)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs6st1 Mutation: 26 strains or lines available

References

• Original: J:122656 Habuchi H, et al., Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
• All: 3 reference(s)