Phenotype Image Detail

Image

Caption

A-D: Histological analysis of cardiac valves. Shown are hematoxylin and eosin stained longitudinal sections of hearts of E17.5 embryos. Mice are wild-type (WT, A and C) and Hbegf^tm2Mek/Hbegf^tm2Mek (uc/uc, B and D). Pulmonic (A and B) and mitral valves (C and D) are indicated by asterisks. Aortic and tricuspid valves were also enlarged (not depicted). Bar, 150 um. E: Measurement of cardiac valve size. The largest diameters of each valve in serial sections of E17.5 embryos of wild-type (black dots, n=5) Hbegf^tm2Mek/Hbegf⁺ (blue dots, n=9) and homozygous mutant (red dots, n=4) hearts were measured. pv, pulmonic valve; av, aortic valve; tv, tricuspid valve; mv, mitral valve.

Copyright

This image is from Yamazaki S, J Cell Biol 2003 Nov 10;163(3):469-75, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:86547

Associated Alleles

Symbol	Name
Hbegf^tm2Mek	heparin-binding EGF-like growth factor; targeted mutation 2, Eisuke Mekada

Associated Genotypes

Allelic Composition	Genetic Background
Hbegf^tm2Mek/Hbegf^tm2Mek	involves: 129/Sv * C57BL/6 * CBA